温肾助阳药对甲低阳虚兔五种微量元素变化的影响

The effects of touifying Kidney-Yang herbs on the five trace elements in the liver ,brain,serum and hair of rabbit models with hypothyroid Yand-De-ficiency syndrome

对甲状腺切除兔（阳虚组）、甲状腺切除后灌服温肾助阳方煎剂兔（汤药组），或灌服金匮肾气丸兔（丸药组）和甲状腺假切除兔（对照组）的背毛、血清、肝、脑组织中锌、铜、铁、锰、铬５种元素进行检测，结果表明①阳虚组肝、脑中锌／铜值下降（Ｐ＜０．０２５或０．０１），肝以铜高为主（Ｐ＜０．０１），脑以锌低为主（（Ｐ＜０．０７５）；②４组兔背毛、血清各元素测定值自身前后及组间比较均无显著性，与同体测定肝、脑中的变化不符，故以前二者的变化推测体内重要器官的变化是不可靠或不敏感的；③两种助阳药可使造型兔肝、脑中元素的异常改变发生逆转，同时也可使其它元素出现变化，故中药的作用机理十分复杂，加之灌服中药中所含元素量甚低，揭示中药的作用不是或不主要是对病体进行简单的元素补充。

In four group female New zealang Wbite rabbits,i.e,thyroidectomized(G1),thyroidectomized and treated with a decoction composed of tonify-ing Kidney-Yang herbs(G2),or a pill Jing Gui Sheng Qi Wan(G3)and controls(G),the five trace elements(Zn,Cu,Fe,Mn,Cr)of the liver,brain,serum,and back hair were determined with ICP-atomic emmision spectropho-tometry,The results indicated that;①The Zn/Cu values in the liver andbrain of G1 decreased significantly(p<0.025～0.01),for the liver this decrement was caused by Cu increased mainly (P<0.01),while for the brain by Zndecreased mainly(P<0; 075). ②The changes of five elements in serum and back hair of four groups were not significant,and didn,t correspond with thechanges in liver and brain, so it might be unreliable to deduce the changes of the latter according to the changes of the former。③A bove Chinese herbs couldameliorate the changes of trace elements and improve the symptomes。 These herbs could not only recover the abnormal element contents, but also changethe proper contents of other elements,so the effective mechanism of these herbs might be an action of complex regulation.1t:effectiveness might not be re-alized by providing elements,because the contents of elements in the decoctions were seldom.