益元活血方治疗老年人腔隙性梗塞的观察及其对血小板功能的影响

Effect or Prescription Tor Supplementing Primordial Qi and Activating Blood Circulation on Platelet Function In Lacuna Infarction or the Aged

运用益元活血方治疗老年人腔隙性梗塞(LI)并观察该方对血小板最大聚集率(MAR)、电泳率(EPM)及α颗粒膜蛋白-140(GMP-140)的作用.结果表明:益元活血方治疗组的疗效优于对照组(p<0.01).与老年人健康组比较,LI组MAR和GMP-140水平升高,而EPM水平降低.治疗组和对照组治疗后,MAR降低和EPM水平升高;治疗组GMP-140下降明显.治疗组的MAR、GMP-140的降低和EPM水平升高较对照组有显著差异.提示:益元活血方治疗老年人LI的机理与其抑制血小板聚集释放有关.

In this study,prescription for supplementing primordial qi and activating blood circulation was applied to treat lacuna infarction of the aged and its effect on maximun platelet aggregation ratio (MAR), EPM and GMP-140 were observed. It was found that the effect of this prescription treated group was much better than that of control group (p <0. 01). MAR, GMP-140 were higher and EPM was lower in treated group than those in healthy group. MAR,GMP-140 were decreased and EPM was increased both in treated group and control group after treatment, the decrease of GMP-140 in treated group was more significant than in control group. The changes of MAR. GMP-140 and EPM between the two groups has significant statistical difference. Above results suggested that the therapeutic mechanism of this prescription in treating lacuna infarction is related to its function of inhibiting the platelet aggregation and release.