P物质能神经阻滞剂治疗常年性变应性鼻炎的临床疗效及作用机理

Clinical Observation and Therapeutic Mechanism of Blocking Agent of Substance P Nerves in the Treatment of Perennial Allergic Rhinitis

用辣椒素（ＣＡＰ）鼻腔局部给药，治疗５０例常年性变应性鼻炎患者，每周一次，４次为一疗程，并用Ｐ物质（ＳＰ）放射免疫测定法，在治疗前及治疗后分别测定患者鼻分泌物中的ＳＰ含量，结果表明经ＣＡＰ治疗后临床症状明显缓解，同时治疗后鼻分泌物ＳＰ含量（１６．８４８±１０．６２２ｐｍｏｌ／Ｌ），比治疗前（２９．４４４±１４．２８０ｐｍｏｌ／Ｌ）明显降低（Ｐ＜０．００１）。５０例中临床显效３５例（７０．０％），有效１２例（２４．０％），无效３例（６．０％），总有效率９４．０％。提示ＣＡＰ对常年性变应性鼻炎患者的治疗作用与降低ＳＰ水平、阻断ＳＰ能神经轴索反射有关。

This paper reported the clinical effects and therapeutic mechanism of blocking agent ofsubstance P(SP) nerves on prerennial allergic rhinitis. We applid capsaicin(CAP)in the treatment of50 cases of perennial allergic rhinitis once a week and 4 times as a therapeutic course. By using highlyspecific and highly sensitive SP radioimmunossay,the SP contents in nasal secretions were determinedbefore and after CAP therapy.The results showed that clinical symptoms of allergic rhinitis were obvi-ouslv relieved and SP content in the nasal secretions was remarkably reduced from 29.444±14.280pmol/L before CAP therapy to 16. 848±10.622pmol/L after therapy(P<0. 001).of the 50cases, 35 cases(70.0%)showed the best effects,12 cases(24.0%)better effects and 3 cases (6.0%)no effects. The total effective rate was 94.0%. The study indicated that therapeutic mechanism of CAPon perennial allergic rhinitis is related to the reducing of SP and the blocking of axonal reflex of the SP erves.