涂阳肺结核病人乙型肝炎病毒感染流行病学研究

THE EPIDEMIOLOGICAL STUDY OF HEPATITIS B INFECTION IN SMEAR POSITIVE TUBERCULOSIS CASES

目的:掌握涂阳肺结核病人乙型肝炎病毒感染状况,并为现代结核病控制策略的措施改进提供参考。方法:伴随河南省第二轮结核病耐药监测,对监测入选病人进行乙型肝炎抗原抗体系统5项指标血清学和肝功能检查。结果:乙肝病毒感染率为39.8%;HBV-M阳性者(除抗-HBs外)肝损率明显高于HBV-M阴性者。结论:涂阳肺结核病人感染率与普通人群相似;应关注HBV-M阳性者的肝损情况;建议在抗痨治疗后为传染性肺结核患者提供一次免费肝功能检查和肝功异常者必要的保肝药物。

Objective:To research the prevalence rate of hepatitis B infection in smear positive case, and to provide reference data for the improvement of the on-going tuberculosis control measures of the DOTS strategy.Methods:WTThis study was carried out together with the second drug resistance surveillance in tuberculosis in Henan organized by WHO. HBV-M and liver function were tested for the enrolled patients.Results:The prevalence rate of Hepatitis B infection was 39.8%. The liver function disorder rate of the smear positive tuberculosis cases with HBV-M positive was significantly higher than those with HBV-M negative.Conclusion:The prevalence rate of Hepatitis B infection in smear positive tuberculosis cases is similar with that in general population. Their liver function should be observed for tuberculosis cases with HBV-M positive during their anti-tuberculosis treatment.It is suggested that a free liver function test and the necessary liver-protection medicines for those whose liver function is disorder should be provided.