老年心绞痛发作时测定细胞粘附分子的临床意义

DETECTION OF SERUM CELLULAR ADHESION MOLECULE AND ITS VALUE IN PREDICTION OF ANGINA PECTORIS IN ELDLY PATIENTS

目的:探讨P-选择素、OX-LDL、NO水平在老年心绞痛发作中的临床意义。方法:测定64例老年心绞痛患者和36例健康老人的血清P-选择素、OX-LDL、NO水平。结果:病例组血清P-选择素(1.90±0.89mg.L1)、OX-LDL(1.56±0.51mg.L1)、比对照组(0.89±0.31mg.L1,0.76±0.16mg.L1)明显增高,NO明显降低(68.50±13.42mmo1.L1vs119.87±26.86mmo1.L1,P<0.05-0.01);相关分析发现P-选择素与OX-LDL呈显著正相关(r=0.69,P<0.01),与NO呈显著负相关(r=-0.75,p<0.01)。调脂治疗后病例组血清P-选择素、OX-LDL水平明显降低(1.25±0.37mg.L1,0.91±0.36mg.L1,P<0.01),NO水平明显回升(112.25±27.76mmo1.L1,P<0.01)。结论:提示动脉斑块炎症反应在心绞痛发作中有重要地位。P-选择素、OX-LDL、NO水平是其灵敏预测指标。

Objective:To explore the relationship between P-selection oxidized low density lipoprotein (OX-LDL) and nitric oxide (NO) and oneset of angina pectoris.Methods: The levels of serum P-selection,were measured in 64 elderly patients with angina pectoris and 36 normal controls.Results:The levels of serum P-selection(1.900.89 mgL^(-1)) and OX-LDL (1.560.51 mgL^(-1)) were higher and the level of serum NO (68.5013.42 mmo1L^(-1)) was lower in group of patients than that of normal controls (0.890.31 mgL^(-1),0.760.16 mgL^(-1),119.8726.86 mmolL^(-1)). P-selection was positive correlated with OX-LDL(r=0.69,P<0.01) and negative correlated with NO (r=-0.75,P<0.01).The serum P-selection and OX-LDL reduced (1.250.37 mgL^(-1), 0.190.36 mgL^(-1)) and serum NO elevated (112.2527.76 mmolL^(-1),P<0.01) by the intervention of lipid lowing in the group of patients.Conclusion:Inflammatory infiltration infliltration in the coronary arteriosclerotic lesions is important in oneset of angina pectoris and it was blocked by the intervention of lipid lowing.