大肠癌中的内分泌型癌细胞及其临床生物学意义

The Frequency and Clinical Biological Significance of Endocrine Cells in Colon Cancer

应用嗜银染色及免疫组织化学方法对４２例大肠癌中的内分泌型癌细胞进行了检测和激素产物分析，并对内分泌型癌细胞的临床生物学意义进行了探讨。结果显示：１）在大肠癌中内分泌型癌细胞的阳性率为２８．５７％（１２／４２），激素产物分析中以血清素是多见；２）内分泌型癌细胞的出现与分化程度，肿瘤分期和淋巴结转移无关。结果提示：大肠癌中存在内分泌型癌细胞的分化，但不影响肿瘤的临床生物学行为。

Neoplastic endocrine cells and hormone products were studied in 42 cases of large intestinal carcinoma by immunohistochemistry and Grimelius sliver stain, and their clinical biological significance was investigated. The results showed that: (1) the positive rate of neoplastic endocrine cells was 28. 57% (12/42) in large intestinal carcinoma and that serotonin was found frequently; (2) the presence of neoplastic endocrine cells was not related to the degree of differentiation, the staging of the disease and the rate of lymphatic metastasis. The findings suggest that the presence of neoplastic endocrine cells could develop in large intestinal carcinoma, nevertheless it does not affect the clinical biological behavior.