尿钙检测对妊高征的预测价值

Predictive Value of Urinary Calcium Measurement on Occurrence of Pregnancy-Induced Hypertension

测定了１８４例正常妊娠妇女及３０例妊高征患者２４小时尿钙总量，尿钙含量及钙／肌酐比值。结果：妊高征患者尿钙总量，尿钙含量及钙／肌酐比值均明显低于正常妊娠妇女。其中１８４例正常妊娠妇女中有２１例发展为妊高征。以尿钙含量为３ｍｍｏｌ／Ｌ及钙／肌酐比值０．０４为界限值，预测妊高征的敏感性分别为７６．２％及８１．０％，特异性分别为９７．５％及９８．２％。提示：尿钙的变化可作为妊高征的预测指标。

Objective To study the predictive value of urinary calcium excretion on occurrence of pregnancy- induced hypertension (PIH). Methods Twenty-four-hour urinary calcium excretion, urinary calcium concentration and urinary calcium /creatinine (Ca/Cr) ratio were determined in 184 normal pregnant women and 30 patients with PIH. Results Twenty-fouf-hour urinary calciutn excretion, urinary calciurn concentration, and Ca/Cr ratio in PIH group were significantly lower than that in normal pregnant group (P < 0.01). 3mmol / L of urinary calcium concentration and 0.04 of Ca/Cr ratio were chosen as predictive thresholds for develo- pment of PIH , with sensitlvity of 76.2% , 81.0% and specificity of 97.5% , 98.2% respectively. Conclusions Low urinary calcium excretiOn is a valuable marker for prediction of PIH.