血管紧张素Ⅱ升压化学疗法治疗中晚期肺癌的临床观察

Clinical Observation of Chemotherapy Combining with AugⅡ in Advanced Lung Cancer

目前对于失去手术机会的中晚期肺癌，多采用全身较大剂量抗癌联合化疗，如何提高其疗效并减少副作用，成为国内外肿瘤治疗界期待解决的课题。最近我们经研究发现血管紧张素Ⅱ（ＡｕｇⅡ）升高血压，正常组织的血流不变或减少，而肿瘤血流则数倍增加，在血流增加的高峰，全身应用抗癌药物，可明显提高肿瘤化疗效果。我院自１９９２年４月至１９９３年１月应用ＡｕｇⅡ升压加ＡＤＭＰ方案联合化疗与单纯ＡＤＭＰ全身化疗各３０例进行了对照观察，其结果表明应用ＡｕｇⅡ升压加ＡＤＭＰ方案联合化疗组近期疗效明显高于单纯ＡＤＭＰ化疗组，Ｐ＜０．０５。不仅短期内肿瘤明显缩小，而且脱发、食欲不振的副作用明显减轻，实为治疗中晚期恶性肿瘤的新途径。此方法操作简单易行，有广泛的使用价值。

It has been demonstrated that angiotensinⅡ (AugⅡ) could in crease blood Pressure in cancer tissue, but not in normal tissues. At high blood pressure Phase more anticancer drugs injected into the body would reach the cancer site. From April 1992 to January 1993, 30 cases of unresectable lung cancer patient were treated by combined chemotherapy (ADMP scheme) with AugⅡ. Another 30 casesof advanced lung cancer were treated with the same ADMP scheme without AugⅡ as control. The effective rates in the two groups were 80% and 40% respectively (P<0.05),and alopecia and anorexia were less in the test group. The authors considered that this method may be also more effective than conventional chemotherapy in other cancer treatment.