超重高血压患者与心血管危险性相关的探讨

Relationship Between Overweight Hypertensives and Cardiovascular Risk

目的:探讨超重高血压患者与心血管危险性的关系。方法:145例原发性高血压患者按体重指数(BMI)分为2组:超重组90例(BMI≥25kg/m2),非超重组55例(BMI<25kg/m2),比较2组主要心血管危险因素水平及临床特征。结果:超重组较非超重组总胆固醇、甘油三酯、血糖、C反应蛋白及纤维蛋白原增高,而高密度脂蛋白胆固醇降低(P<0.05);收缩压均随着BMI的增加而明显增高;超重组颈动脉斑块的发生率增高,心脏射血分数下降,冠心病、糖尿病、高血脂的患病率增加,2组比较均有显著性差异(P<0.05)。结论:超重高血压患者应积极减重并控制到正常范围,对预防心血管疾病的发生及发展有重要意义。

Objective:To study the relationship between overweight hypertension and cardiovascular risk. Methods:One hundred and forty five patients with hypertension were divided into two groups according to body mass index(BMI),overweight group(BMI≥25 kg/m2),and non-overweight group(BMI<25 kg/m2).The cardiovascular risk and clinical features were compared between groups. Results:In overweight hypertensives,mean total cholesterol(TC),triglycerides(TG),glucose(GLU),C-reactive protein(CRP)and fibrinogen(FIB) were significantly higher,whereas mean high-density lipoprotein cholesterol(HDL-C)was significantly lower than those of non-overweight group (p<0.05).Systolic blood pressure(SBP) was increased as the inerease of BMI and showed statistical difference between groups(p<0.05).The incidence rate of atherosclerotic plaque of carotid artery in the overweight group was higher than in the non-overweight group (p<0.05).Ejection fraction(EF) was lower than non-overweight group.The incidence rate of coronary heart disease(CHD),diabetes mellitus(DM)and high lipids in the overweight group were higher than in the non-overweight group (p<0.05). Conclusion:Patients with overweight hypertension should lose their body weight and keep it within the normal range.This is of great importance in prevention of cardiovascular disease.