汕头地区417例疑似脊髓灰质炎病因分析

ETIOLOGICAL ANAL YSIS OF417CASES SUSPECTED OF POLIMYELITIS IN SHANTOU ARBA

对汕头地区１９７１～ｌ９９２年临床疑似脊髓灰质炎（灰髓炎）４１７例患者粪便标本和９４例患者双份血清，进行了病毒病因检测，结果分离出病毒１９２株，检出率为４６．０％，计有灰髓炎病毒１５６株，其中Ⅰ型病毒１３８株，占灰髓炎阳性的８８．５％。柯萨奇病毒１０株，埃可病毒和腺病毒各８株，肠道７１型病毒７株，未定型病毒３株。对１１４株灰髓炎Ⅰ型病毒进行了型内抗原分析，结果表明，不同时期分离的灰髓炎Ⅰ型病毒其抗原性有明显差异。在１９８９年以前分离到的灰髓炎Ⅰ型病毒，不论是流行期还是散发病例，均以灰髓炎野毒变异株为主，而１９８９～ｌ９９２年流行的灰髓炎Ⅰ型病毒株则以野毒株Ｍａｈｏｎｅｙ株及其变异株为主要流行毒株。

iral studies were done on 4 1 7 cases,suspected of poliomyelitis in Shantou area from l9 71～1992 inclusive.Altogether stool samples from 4 1 7 cases,and sera from 94 cases were collected.The result showed that l9 2 of these cases were positive for viral isolation,the positive ratc was 46%. Among these,there were l5 6 strains of poliovir- uses,10 of coxsackie viruses,8 ECHO viruses,8 adenoviruses,7 Enteroviruses 71 and 3 strains undefined.The subtype antigen of 114 poliovirus I strains analysed was the result showed that the antigenicity of the isolated polioviruses I was distinctly different in different periods.Before l989 the polioviruses l were mainly wild strains, no matter whether it was isolated in epidemics or in sporadic period,from l989 to l992 the isolated pol ioviruses I were mainly Mahoney wild strains and its variant strains.