糖皮质激素及异烟肼预防食管碱性腐蚀伤后瘢痕狭窄的实验研究

The Effects of Glucocorticoid and Isoniazidum on Prevention of Scar Stenosis after Esophageal Corrosive Injury

实验家犬采用Ｄａｖｉｓ食管碱性腐蚀伤模型，结果显示：甲基强的松龙治疗组，狭窄段食管的管径和食管的顺应性均明显大于对照组，而胶原含量及图象分析瘢痕组织中胶原纤维的密度均显著低于对照组，表明甲基强的松龙确有控制食管腐蚀伤后瘢痕狭窄的作用。但异烟肼组所测得的上述指标，均显著优于甲基强的松龙组，说明异烟肼预防食管腐蚀伤后瘢痕狭窄的效果优于甲基强的松龙，且其不良反应小，可以长期应用。无论甲基强的松龙或异烟肼，如同时应用青霉素均可加强治疗效果。

Experimental results of methylprednisolone and isoniazid to prevent scar stenosis after esophageal corrosive injury are reported in this paper.The model of Davis's esophageal corrosive injury was used in all dogs.The results showed that the diameter and complince of esophagus in the methylprednisolone group were significantly bigger than those in the control group.The collagen concentration and collagen density analysed by the image of scar tissue in the methylprednisolone group were significantly lower than those in the control group.It is suggested that the methylprednisolone alleviated the esophageal corrosive stenosis.Furthermore,the indexes mentioned above in the isoniazid group were still better than those in the methlprednisolone group.It indicated that the prophylactic effect of isoniazid on esophageal corrosive stenosis was more excellent than that of methylprednisolone.The toxic reaction of isoniazid is also less and can be administrated for a long period.It also showed from this research that whether methylprednisolone or isoniazid combined with penicillin could obviously increase the effects on prevention of scar stenosis after easophageal corrosive injury.(Original article on page 161)