脑外伤后外周血淋巴细胞产生白介素-2能力与急性期蛋白变化的相关性研究

A Study of the Correlation Between PBLIL 2P and APRPs in Patients with Moderate or Major Brain Injuries

对２２例中重型脑外伤病人（ＧＣＳ３～１２分）外周血淋巴细胞产生白介素－２能力（ＰＢＬＩＬ－２Ｐ），急性期蛋白（ＡＰＲＰｓ）包括血浆铜兰蛋白（ＣＰ）、α１－酸性糖蛋白（α１－ＡＧ）、α１－抗胰蛋白酶（α１－ＡＴ）、Ｃ反应蛋白（ＣＲＰ）、纤维结合蛋白（Ｆｎ）和补体Ｃ３成份Ｃ片段（Ｃ３ｃ）等指标进行了观察研究．结果发现：中重型脑外伤后ＰＢＬＩＬ－２Ｐ（代表细胞免疫功能状态）下降，而ＡＰＲＰｓ中ＣＰ、α１－ＡＧ、α１－ＡＴ、ＣＲＰ升高，Ｆｎ和Ｃ３ｃ降低．相关性分析结果：ＰＢＬＩＬ－２Ｐ的降低与ＣＰ、α１－ＡＧ、α１－ＡＴ及ＣＲＰ的增高均呈直线负相关（ｒ＝－０．６５，－０．６３，－０．５８，－０．５７），且均相关显著（Ｐ＜０．０１），与Ｆｎ、Ｃ３ｃ的降低均呈直线正相关（ｒ＝０．６９，０．７１），且相关显著（Ｐ＜０．０１）．表明ＡＰＲＰｓ对细胞免疫功能有一定调控作用．

Twenty two patients with moderate or major brain injuries were observed clinically.The indexes,peripheral blood lymphocyte interleukin 2 productivity (PBLIL 2P),and the acute phase reaction proteins (APRPs) including ceruloplasmin (CP),α 1 acid glycoprotein(α 1 AG),α 1 antitrypsin(α 1 AT),C reaction protein(CRP),fibronectin (Fn) and complement 3c (C3c) etc,were examined.The results showed that PBLIL 2P decreased,CP,α 1 AG,α 1 AT and CRP increased and Fn and C3c reduced in these patients. The correlation coefficient ( r ) between PBLIL 2p and CP was -0.65 ( P <0.01),α 1 AG -0.63( P <0.01),α 1 AT -0.58 ( P <0.01) ,CRP -0.57 ( P <0.01),Fn 0.69 ( P <0.01) and C3c 0.71 ( P <0.01).The results indicated that APRPs regulated the cellular immunity.(Original article on page 224)