白癜风患者血清α2-巨球蛋白测定的临床意义

Clinical Significance of Determination of Serum α 2-macroglobulin in Patients with Vitiligo

目的探讨血清α2巨球蛋白(α2M)水平变化与白癜风的关系及临床意义。方法采用免疫扩散法对79例白癜风患者进行血清α2M水平及免疫球蛋白IgG,IgA,IgM浓度的测定,与正常对照组比较分析。结果与对照组相比,白癜风寻常型与节段型血清α2M水平均显著性升高(P<0.01,P<0.05),以寻常型中进展期尤甚;白癜风患者血清中免疫球蛋白IgG,IgA,IgM的浓度也有显著性变化;血清α2M水平的升高与免疫球蛋白浓度的变化相一致。结论白癜风患者血清α2M水平的升高与白癜风的发病有一定关系。

Objective To investigate the clinical significance and correlation between serum levels of α 2-macroglobulin (α 2-M) and vitiligo.Methods Immune diffusion methods were used to determine the serum levels of α 2-M and immunoglobulin IgG,IgA and IgM in 79 patients with vitiligo.Results The serum level of α 2-M in patients with the vulgaris type and segmental type of vitiligo was significantly higher than those in healthy people(P<0.01,P<0.05),especially in the progressive period serum level of α 2-M and the concentration of immunoglobulin.Conclusion There was correlation between the serum level of α 2-M and the pathogenesis of vitiligo.