水蛭治疗原发性肾病综合征高粘滞血症

THERAPEUTIC EFFECT OF HIRUDO ONHYPERVISCOSITY SYNDROME IN CHIL-DREN WITH PRIMARY NEPHROTIC SYN-DROME

运用中西医结合方法观察水蛙治疗原发性肾病综合征（简称肾病）患儿高粘滞血症的疗效，检测其血液流变学改变、血小板及血浆血栓烷Ａ＿２（ＴｘＡ＿２）、前列环素浓度。结果表明，无论单纯性肾病或肾炎性肾病的高粘滞血症，水蛭加泼尼松治疗组与单独泼尼松治疗组相比，血浆粘度恢复正常无数、尿蛋白消失天数及水肿消失天数均明显减少。单纯性肾病或肾炎性肾病与对照组相比，３．８／ｓ、９．６／ｓ、１９．２／ｓ、３８．３／ｓ、７６．８／ｓ、１９２／ｓ、３８３／ｓ等切变率下的血液粘度、血浆比粘度、红细胞沉降率、红细胞压积、血小板计数、血小板粘附率、最大聚集率、血浆ＴｘＢ＿２浓度及ＴｘＢ＿２／６－酮－前列腺素Ｆ＿１ａ民。的比明显升高。说明肾病患儿存在高凝状态，水蛭具有治疗肾病高粘滞血症的作用。

ith the method of tradrtional Chinese medicineconibined with western medicine, we studied the thera-peutic effect of hirudo on hyperviscosity in children withsimple and nephritic nephrotic syndrome and determinedhemorrheological change . platelet . the concentration ofplasma thromboxane A_2 (TxA_2 ) and prostacyclin(PGI_2). Compared with hyperviscous patients who tookprednisone, the time during which plasma viscosrty,urinary protein and edema becanie normal was signifi-cantly shorter in patients who took both hirudo andprednisone. Blood viscosrty of 3. 8/s, 9. 6/s, 19. 2/s,38. 3/s, 76. 8/s, 192/s and 383/s shear rate. plasmaviscosity, erythrocyte sedimentation rate, hematocrit,peripheral platelet count, platelet adhesion rate. maxi-mum platelet aggregation rate , concentration of plasmathromboxane B_2 (TxB_2) and TxB_2-6-Keto-PGF ratioincreased significantly in simple and nephritic nephroticsyndrome group as compared with the control group.These results suggest that there is hypercoagulability innephrotic children and that hirudo is effective againsthyperviscosity syndrome in such children.