新生儿尿微量蛋白检测的临床意义

CLINICAL SIGNIFICANCE OF URINETRACE AMOUNT PROTEIN DETECTIONIN NEWBORN INFANTS

用酶联免疫吸附法检测３０例感染新生儿入院时及应用氨基糖甙类组、半合成青霉素３、７、１４天后尿微量蛋白变化，并与正常健康新生儿对比。发现入院时两组尿微量蛋白无明显改变，用药后，氨基糖甙类组尿微量蛋白升高，最早可发生在用药３天后；半合成青霉素组于用药１４天后升高。升高的尿微量蛋白为白蛋白与ＩｇＡ，反映损害主要在肾小管。认为尿微量蛋白检测有助于及早判断新生儿肾损害，可辅佐尿微球蛋白测定，作为筛查指标。

he variations of trace amount protein (TAP) inurine were detected with ELISA method in newborninfants with recent infections on admission and 3, 7 ,14 days after hospitalization. The patients were dividedinto 'Aminoglycoside' and 'Semi-synthetic penicillins'groups, which were compared with a group of healthynew borns. We found that the difference in urine TAPvariation between infected and control groups werenonsignificant on admission, 3, 7, and 14 days afteradmission both in 'Aminoglycoside' and 'Semi-synthe-sized ampicillin' groups, the increment of urine albu-min and IgA had been consequently found. There wassignificant difference between the specimens collectedbefore and after treatment in the group with infectionsand healthy newborns- In `Aminoglycoside' group,the occurence of urine albumin and lgA appeared earlier, on day 7 after admission : while in 'Semi-syntheticPenicillin' group, they appeared on day 14. These re-sults suggest that all the above-mentioned antibioticsmay lead to renal damage, and that the main damagesite is renal tubules.The urine TAP detection methed is simple andvery sensitive, which may be used in screening for re-nal damage caused by nephrotoxic drugs and other fac-tors.