过敏性紫癜白细胞介素2水平及其受体表达

IL-2 AND EXPRESSION OF IL-2 RECEP-TOR IN CHILDREN WITH HENOCH-SCHONLE IN PURPURA

采用￣３Ｈ－ＴｄＲ掺入法检测急性期过敏性紫癜患儿白细胞介素２（ＩＬ－２）水平，同时用抗Ｔａｃ单克隆抗体以ＡＰＡＡＰ方法检测外周血淋巴细胞中白细胞介素２受体阳性细胞（ＩＬ－２Ｒ￣＊）及用ＥＬＩＳＡ方法检测血清中可溶性白细胞介素２受体（ＳＩＬ－２Ｒ）水平。结果显示急性期过敏性紫癜患儿ＩＬ－２水平和ＩＬ－２Ｒ￣＋细胞均比正常对照组显著降低（Ｐ＜０．０１），血清中ＳＩＬ－２Ｒ水平与正常对照组相比显著升高（Ｐ＜０．０１）。提示，在过敏性紫癜的发病机制中ＩＬ－２和ＩＬ－２Ｒ具有重要意义。

he Levels of IL-2 in peripheral blood of acuteHenochSchonlein Purpura (HSP) was examined by3H-TdR minglei IL-2R￣+ cell in cases of acute HSPwas measured by anti-Tac antibodies and APAAP;levels of SIL-2R were examined bv ELISA. The re-sults showed that Levels of IL-2 and IL-2R￣+ in patientswith HSP were lower than those in normal group ; ley-els of SIL-2R in patients with HSP were higher thanthose in normal group. It is suggested that IL-2 andIL-2R play an important role in pathogenesis of HSP.