风湿热、风湿性心脏病与血脂关系的探讨

A STUDY ON SERUM TOTAL CHOLES-TEROL , HDL CHOLESTEROL ANDTRIGLY-CERIDE LEVELS IN CHILDRENWITH ACUTE RHEUMATIC FEVER ANDRHEUMATIC HEART DISEASE

报告风湿热（ＲＦ）和风湿性心脏病（ＲＨＤ）患儿５３例，正常对照８１例，均检测其血清总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）。结果：ＲＦ／ＲＨＤ组的ＴＣ、ＴＧ、ＨＤＬ－Ｃ明显低于对照组，其相对危险度为对照组的３．１５～５．７８倍；ＴＣ、ＴＧ、ＨＤＬ－Ｃ血清值与相对危险度呈反比。提示血中保持一定的ＴＣ、ＴＧ和ＨＤＬ－Ｃ浓度水平，对于预防ＲＦ／ＲＨＤ的发病是有益的。

his paper describes a casecontrol study on serumlipids among children with acute rheumatic fever andrheumatic heart disease (ARF/RHD) and controlgroup. Fifty-three cases of ARF/RHD aged 7～14years were from Guangdong Cardiovascular Instituteduring 1991 to 1992. The diagnosis of ARF was basedon the modified Jones' crrteria (1982). The resultsshowed that the serum level of total cholesterel (TC)was 4. 33 mmol/L in RF/RHD group versus 5.31mmol/L in control group (P<0. 01 , OR = 4. 99) ; Theserum level of HDL cholesterol (HDL-C) was 0. 92mmol/L in RF/RHD group and 1. 17 mmol/L in con-trol group , respectively (P< 0.01 , OR=5. 78) ; andthat of TG was 1. 18 mmol/L in RF/RHD group and1. 52 mmol/L in control group , respectively. The lipidlevels in the former was lower than in the latter (P<0. 05). In conclusion , the levels of serum lipids in RF/RHD group were lower than those in control group.Their ORs were 3. 15 to 5. 78 times as high as in con-trol group , and the lower the level of serum lipids, thegreater ORs. These results suggest that maintainingproper level of serum lipids in children may be of somehelp in prevention of RF/RHD.