新生儿感染性疾病白细胞介素2受体和IgG_4水平的测定

DETECTION OF INTERLEUKIN 2 RECEP-TOR AND IgG4 IN NEONATAL INFEC-TIOUS DISEASES

应用三抗体和双抗体夹心ＥＬＩＳＡ法，测住院新生儿感染性疾病和对照组各２０例的血清可溶性白细胞介素２受体（ＳＩＬ－２Ｒ）和血清、唾液ＩｇＧ_４水平。结果患儿组ＳＩＬ－２Ｒ为３０７±３６ｋＵ／Ｌ，对照组为１９８±３２ｋＵ／Ｌ（Ｐ＜０．０５）；患儿组血清ＩｇＧ_４为３９．２±６．５ｍｇ／Ｌ，对照组为１８．２±２．０ｍｇ／Ｌ（Ｐ＜０．０１）；患儿组唾液ＩｇＧ_４为０．１６７＋０．０３６ｍｇ／Ｌ，对照组０．０５５±０．０１４ｍｇ／Ｌ（Ｐ＜０．０１），患儿组三项指标均高于对照组。提示新生儿时期对感染有一定的免疫反应能力。

y using a three-step and two-step sandwichELISA technique,We measured levels of serum inter-leukin 2 receptor(IL-2R)as well as serum and salivaIgG4 in 20 cases of neonatal infectious diseases.Theresults showed that the level of serum IL-2R was sig-nificantly higher than normal controls(307±36vs.198±32 kU/L);serum IgG4 and salive IgG4 were al-so significantly higher than thse of controls(39.2±6. 5 vs.18.2±2.0,0.167±0.036 vs 0.055±0.014mg/L,P<0.05,0. 01,respectively).These re-sults suggested that the immunity against infections al-ready exists to some extent in neonatal period.