一氧化氮对缺氧和急性肺损伤犬的血液动力学与气体交换的影响

THE EFFECT OF INHALED NITRIC OXIDE ON HEMODYNAMICS AND GAS EX-CnANGE OF DOGS WITH HYPOXIA ANDACUTE LUNG INJURY

应用化学发光法监测氮氧化物浓度，观察１０只缺氧和急性肺损伤犬在吸入不同浓度一氧化氮（ＮＯ）时血液动力学和气体交换功能的变化。结果显示，５～５０ＰＰＭＮＯ均可降低缺氧犬肺动脉压２５％±３％（Ｐ＜０．０１），降低肺血管阻力３７％±５％（Ｐ＜０．０１），并使急性肺损伤犬的动脉血氧分压／吸入氧浓度（ＰａＯ＿２／ＦｉＯ＿２）比值上升３３．４±２．３（Ｐ＜０．０５），肺内动静脉分流量与总血流量（Ｑ＿ｓ／Ｑ＿Ｔ）比值下降５％±２％（Ｐ＜０．０５）。提示，低浓度ＮＯ（５～２０ＰＰＭ）即可有效降低缺氧性和急性肺损伤犬肺动脉高压并改善其动脉氧合功能。

e examined the effects of inhaled nitric oxide(NO) on hemodynamics and oxygenation in dogs withhypoxia(n=5)and acute lung injury (ALI) (n=5)The results showed that inhaled NO (5-50ppm)signif-icantly lowered mean pulmonary artery pressure(mPAP)(P<0.01) and pulmonary vascular resis-tance (PVR)(P<0.01)in dogs with pulmonary hy-pertension (PH); PaO_2/FiO_2 was increased by 33.4±23(P<0.05) and intrapulmonary shunt (Qs/Qr)was decreased by 5±2%(P<0.05). We concludethat inhaled NO( 5-50ppm)lowers mPAP and PVR indogs with PH and improves oxygenation without caus-ing adverse systemic hemodynamic effects.