鼻粘膜内源性抗IgE抗体的诱导及其对IgE水平的抑制作用

Induction of Endogenous Anti-IgE Antibody of Nasal Mucosa and Its Inhibitive Effects on IgE Level

报道在鼻粘膜局部诱导产生抗ＩｇＥ抗体及其对ＩｇＥ水平的抑制作用。经消化法将ＩｇＥ分子断链，提取其中的Ｆｃｅ片段为抗原，对小鼠进行全身和鼻粘膜局部免疫，免疫后不同时间取小鼠血清、脾脏和鼻粘膜组织分别测定抗ＩｇＥ、ＩｇＥ和另外４种免疫球蛋白。结果在免疫后，上述组织中抗ＩｇＥ抗体含量增加，ＩｇＥ抗体含量下降，ＩｇＥ分泌细胞减少，另外４种免疫球蛋白含量无显著变化，这些结果持续到免疫后１４周。结果提示可以人为地在鼻粘膜中诱导产生抗ＩｇＥ抗体，并抑制ＩｇＥ抗体含量，且对机体未见明显不良影响。

The animals were immunized with IgEFcs fraction which conjugated with keyhole limpet hemocyanin locally and systemicly. The levels of anti-IgE, IgE and other four kinds of immunoglobulins were tested from the specimen of nasal mucosa, blood and spleen,The results showed that there were enhanced anti-IgE levels and depressed lgE levels,and there were no significant changes in the other four kinds of immunoglobulins after being immunized with lgEFce fractions, These effects continued un-til l4 weeks after immunization. These data demonstrate that there are possibilities to induce anti-IgE antibody in nasal mucosa locally and inhibit IgE antibody without significant side effects on the body.