摘要
应用增殖细胞核抗原(PCNA)单克隆抗体PC10免疫组化法、DNA图像分析法及核分裂像计数法对70例喉鳞状细胞癌的增殖活性进行检测。结果显示,王种方法的检测结果具有较好的一致性。细胞增殖活性与喉癌的组织学分化程度及患者的五年生存率有密切关系(P<0.01,P<0.01)。结果表明,检测肿瘤细胞增殖活性对于判断喉癌的恶性度及估计患者的预后具有重要的意义。
Cellular proliferation indices such as proliferating cell nuclear antigen(PCNA) ,DNA content index and mitotic figure counts ( MFC )were evaluated in 7 0 cases of laryngeal squamous cell carcinoma. The results showed that there were strong correlations between these indices and histological grading of the carcinoma(P<0. 01,P<0.01, P<0.05).Both PCNA index and MFC were related to the five-year survival rate(P<0. 01).The PCNA Iabelling index was corresponded with both DNA in-dex and MFC(r=0. 61,P<0. 001;r=0.76,P<0. 001)。Our data suggest that cellular proliferation of laryngeal carcinoma can be reliably assessed with three different methods and these indices can be used as the predictor of tumor malignancy and prognosis.
出处
《中华耳鼻咽喉科杂志》
CSCD
1995年第5期305-307,共3页
Chinese Journal of Otorhinolaryngology
关键词
喉肿瘤
预后
细胞增殖活性
组织学
单克隆抗体
Laryngeal neoplasms Carcinoma,squamous cell Antibodies,monoclonal Prognosis