四磨汤口服液治疗运动障碍型功能性消化不良50例

Treatment of 50 Patients with Dyskinetic Functional Dyspepsia with Simotang Oral Solution

目的观察中药四磨汤口服液治疗运动障碍型功能性消化不良(FD)的临床疗效。方法100例运动障碍型FD患者随机平均分为两组。治疗组给予四磨汤口服液,对照组给予安慰药。两组均每次口服20mL,tid,餐前0.5h服用,疗程7d。治疗前记录患者的主要症状,并做B超胃排空功能测定。治疗开始后每24h观察患者主要症状的变化情况1次,按分级量化标准进行症状评分,治疗结束后复查胃排空功能。结果治疗组总有效率(治疗指数>30%,胃排空功能好转或恢复正常的患者所占比例)88.0%,对照组为36.0%,两组总有效率差异有极显著性(P<0.01)。治疗组治疗后主要症状总积分明显低于本组治疗前和对照组治疗后,各主要症状积分亦较本组治疗前有显著下降。经B超胃排空时间测定,治疗组治疗后胃半排空时间明显低于对照组治疗后和本组治疗前。结论四磨汤口服液是治疗运动障碍型FD的有效中药制剂。

Objective To study the therapeutic effect of simotang oral solution (SOS) in the treatment of patients with dyskinetic functional dyspepsia (FD). Methods 100 patients with dyskinetic FD were randomly divided into two equal groups. Patients of the treatment group and control group were given each PO 20 mL of SOS and equal amount of placebo 1/2 h. before meal t.i.d.. The course of treatment in both groups lasted 7 days. Major symptoms in patients of the 2 groups were registered before the treatment and the gastric emptying function of the patients was assayed with B-mode ultrasonography. The changing conditions of the major symptoms were kept under observation every 24 h. after the beginning of treatment. Each symptom was scored according to the graded quantified standards. The gastric emptying function was reexamined after the termination of treatment. Therapeutic efficacy was evaluated by the total and single scores of major symptoms and the time of gastric emptying. Results The overall effective rates in patients of the treatment group and control group were 88.0% and 36.0%, respectively, the difference being highly significant (P<0.01). The total scores and single scores of the major symptoms in patients of the treatment group were much lower than those in patients of the control group after the treatment. The time of gastric half-emptying in patients of the treatment group after the treatment was also shorter than that before the treatment and that in patients of the control group after the treatment. Conclusion SOS was shown to be an effective traditional Chinese medicine in the treatment of patients with dyskinetic FD.