奎硫平联合氯硝西泮治疗精神分裂症急性兴奋80例

Treatment of 80 Cases of Schizophrenia Manifesting Acute Erethitic Symptoms with Quetiapine Combined with Clonazepam

目的研究奎硫平联合氯硝西泮治疗精神分裂症急性兴奋的疗效与安全性.方法将精神分裂症急性兴奋患者160例随机分为两组.治疗组80例给予奎硫平口服,100～500mg·d-1,同时给予氯硝西泮肌内注射,2～4mg·d-1;对照组80例给予氟哌啶醇肌内注射,10～20 mg·d-1.疗程均为7 d.治疗期间每日评估阳性和阴性症状量表兴奋条目和不良反应量表.结果治疗组精神分裂症急性兴奋控制有效率为78.0%,对照组有效率为80.0%,两组差异无显著性(P＞0.05).对照组锥体外系不良反应发生率高于治疗组,治疗组常见不良反应有嗜睡、口干、视物模糊、恶心呕吐、眩晕、心动过速、血压降低等.结论奎硫平联合氯硝西泮治疗精神分裂症急性兴奋疗效肯定,安全性优于氟哌啶醇.

Objective To study the therapeutic effectiveness and safety rate of quetiapine combined with clonazepam in the treatment of schizophrenics manifesting acute erethitic symptoms. Methods 160 schizophrenics suffering from acute erethitic symptoms were randomly divided into two equals groups. 80 cases of the treatment group were given each 100-500 mg of quetiapine PO q.d.. and 2-4 mg of clonazepam I.M.q.d.. 80 patients of the control group were given each an I.M. injection of 10-20 mg of haloperidol ,q.d.. The course of treatment in both groups lasted 7 days.During the course of treatment, the Positive and Negative Syndrome Scale-Excited Component (PANSS-EC) and the Treatment Emergent Symptoms Scales (TESS ) were assessed every day. Results The effective rates of quetiapine and haloperidolin in controlling acute erethitic symptoms in the 2 groups were 78.0% and 80.0%,respectively,the difference being insignificant(P>0.05) . The incidence of extrapyramidal adverse reactions in patients of the control group was higher than that of the treatment group. Common adverse reactions in patients of the treatment group were somnolence, dryness of mouth, blurred vision, nausea and vomiting, dizziness, tachycardia, hypotension etc.. Conclusion Quetiapine combined with clonazepam was shown to exert definite therapeutic effect in controlling acute erethitic symptoms of schizophrenics and its safety rate was higher than that of haloperidol.