生殖细胞中辐射诱导适应性反应的研究──Ⅰ　辐射剂量及间隔时间对适应性反应的影响

Induction of adaptive response by radiation in mouse germ cells.1.Relationship between radiation dose,time interval and adaptive response.

本文作者利用小鼠初级精母细胞的短期实验和精原干细胞的长期实验，对低剂量辐射的剂量、照射方式和大剂量辐射的剂量以及间隔时间进行了研究。结果证明；１０～２００ｍＧｙＸ射线都能诱导适应性反应出现；大剂量辐射的剂量水平对适应性反应的影响不太明显，即在０．７５～４．５Ｇｙ之间均可见到适应性反应；小剂量辐射与相继大剂量辐射之间的间隔时间对适应性反应的出现有很大影响，即０．５小时，大于和等于２４小时不出现适应性反应；５０ｍＧｙ×４的多次照射和慢性小剂量照射１．１０Ｇｙ￣（６０）Ｃｏγ射线仍可诱导明显的适应性反应出现。这些结果表明，在生殖细胞中可见到辐射诱导的适应性反应现象。

In this paper the effects of low dose irradiation,large dose irradiation and time interval on the adaptive response in primary spermatocytes and stem cells were studied. The results showed that both low dose X-ray irradiation(10-200mGy) and large dose X-ray irradiation (0.75-4.5Gy) could induce an adaptive response. The span between the low dose and large dose had an obvious effect on the adaptive response,but there was no such response when the span was 0.5 hour or was longer than 24 hours.Four times of irradiation with 50mGy each and the chronic low dose γ-ray irradiation (accumulated dose of 1.10Gy) could still induce the adaptive response in mouse germ cells.