Licam促排^（238）pu的实验研究

An experimental study on removal of ^(238)Pu by Licam.

用山东医大合成的三种Ｌｉｃａｍ（Ｓ）及三种Ｌｉｃａｍ（Ｃ）对２３８Ｐｕ中毒小鼠进行了早期促排试验（中毒后１小时、８小时促排２次）．结果发现：对骨及肝内的钚有促排作用，但不及ＤＴＰＡ；在肾脏则明显增加滞留量，最高者可为盐水对照组的２．６倍，而且在１６天内一直以高滞留状态逐渐下降。而ＤＴＰＡ促排后，肾钚则一直低于对照组。

The effects of six chelating agents,i.e.three Licam(s)and three Licam (c) , obtained from Shandong Medical University,on clearing of 238Pu were intestigated in mice.At 1 and 8 hours after poisoning with 238Pu, these Licam chelates were given, respectivly.The results show that the Licam chelates are effective for removal of 238Pu from bones and liver, but less effective than DTPA.Increased retention of 238Pu in kidneys(up to 2.6 times that for the control group receiving saline solution)was seen with slow decrease during 16 days.In DTPA group,contents of 238Pu in kidneys were lower than those in the control group at all test times.