自然流产夫妇染色体着丝粒点的研究

Study on chromosomal centromeric dots in couples with spontaneous abortion

对２０对自然流产夫妇（流产组）和１０对已生育正常胎儿并无自然流产史的夫妇（对照组）的外周血染色体着丝粒点（Ｃｄ）进行分析。结果：Ｃｄ消失频率，流产组和对照组分别平均为０．３６±０．１５／细胞和０．２２±０．１３／细胞，两组比较，差异有极显著意义（Ｐ＜０．０１）。小Ｃｄ频率，流产组和对照组分别平均为０．３４±０．１４／细胞和０．３９±０．２８／细胞，两组比较，差异无显著意义（Ｐ＞０．０５）。着丝粒点－核仁组织者区（Ｃｄ－ＮＯＲ）融合频率，流产组和对照组分别平均为０．３１±０．２０／细胞和０．２０±０．１９／细胞，两组比较，差异有显著意义（Ｐ＜０．０５）。提示：自然流产夫妇Ｃｄ消失和Ｃｄ－ＮＯＲ融合频率增高，可能是造成自然流产的原因之一，对自然流产夫妇的Ｃｄ频率进行检测，有一定的临床意义。

hromosomal centromeric dots(Cd)of peripheral blcod in 20 couples with spontaneous abortionand 10 normal couples were studied by Cd-banding technique,The frequencies of Cd loss and centromer-ic dots-nucleolar organizer region (Cd-NOR) fusion were 0.36±0.15/cell and 0.3±0. 20/cell in thecouples with abortion,0.22±0.13/cell and 0. 20±0. 19/cell in normal couples respectively. These re-sults showed that frequencies of Cd loss and Cd-NOR fusion in couples of spontaneous abortion were sig-nificantly higher than those in the normal couples.We suggested that the occurrence of spontaneousabortion in human might casually relate to the changes of Cd.