应用蒂洛安后泌乳量的变化

The effect of sodium prasterone sulfate On lactation.

应用放射免疫分析法测定了蒂洛安（硫酸普拉酮钠，ＤＨＡＳ）ｌ００ｍｇ用药组、２００ｍｇ用药组各３０例及对照组６０例孕产妇，在入院时、产后第１天、产后第３天血清中雌二醇（Ｅ＿２）、垂体泌乳素（ＰＲＬ）和血浆中催产素（ＯＴ）的含量变化，并观察其产后泌乳量。结果：蒂洛安用药组与对照组血中Ｅ＿２、ＰＲＬ、ＯＴ含量差异均无显著性，临床观察两组的泌乳量也无显著差别。因此，可以说明：在通常剂量下，即蒂洛安静脉注射每次１００～２００ｍｇ，每周３次，对产妇的乳汁分泌无显著影响。

o study the relationship between sodium prasterone sulfate and lactation, blood samples were col-Lcted from l20 cases。Sixty cases were in study group(at different periods:during the 3rd trimester,and lst,3rd day postpartum)including 30 cases using l00mg sodium prasterone suifate,30 cases(using 200mg sodium prasterone sulfate), 60 cases were in control group.The serum levels of estradiol(E_2),prolactin(PRL)and plasma levels of oxytocin(OT)were measured by radioimmunoassay, and the pro-duction of breast milk was observed. The results showed no statistically significant difference of serum E_2, PRL and plasma OT between (sodium prasterone sulfate) study groups and control groups, and the production of breast milk indicated also no significant difference between the 2 groups。 The conclusion is that low·dose sodium prasterone sulfate(200mg/day, 600mg /week ) did not affect the production of breast milk。