选择性盆腔动脉插管化疗致附壁血栓形成

Chemotherapy through selective pelvic artery catheterization complicated by mural thrombosis

在选择性盆腔动脉造影的基础上，经导管灌注化疗药物治疗恶性滋养细胞肿瘤能增加肿瘤局部药物浓度，提高疗效，并能减少全身副作用。但动脉插管本身可导致并发症，如附壁血栓形成，不容忽视。现报告２例选择性盆腔动脉插管化疗致附壁血栓形成，并结合文献讨论其发生率、发生的相关因素以及防治措施。强调插管技术对预防血栓形成的重要意义，并就是否应用肝素进行预防的问题进行初步探讨。

hrough catheter on uterine artery digital substractive angiography (DSA)intraarterial infusion of chemotherapeutic agents for the treatment of malignant trophoblastic diseases can raise local drug concentration,improve therapeutic results and reduce general side-effects。 But mural thrombosis,a possible complication of intra arterial catheterization, should not be overlooked.This study reports 2 cases of mural thrombosis complication in selective pelvic artery catheterization for chemotherapy.The incidence,relevant factors to its occurrence such as technique of catheterization and the duration of catheter retention,as well as measures of prevention and treatment of mural thrombosis are dis-cussed together with review of literature,With regards to prevention of mural thrombosis,stress is being laid on the importance of the technique of catheterization, Preliminary comments on the prob-lem of heparin administration as a preventive measure of mural thrombosis are made.