恶性肿瘤患者顺铂化疗对血清镁的影响

Hypomagnesemia in patients of gynecologic neoplasms following chemotherapy with cisplatin

对７９例接受以顺铂（ＤＤＰ）为主要化疗药物的妇科恶性肿瘤患者及其对照者进行血清镁检测和临床症状观察。结果：（１）ＤＤＰ化疗后的妇科恶性肿瘤患者血清镁均值明显低于其它各组，差异均有显著性。（２）随着化疗疗程、ＤＤＰ总剂量和消化道反应程度增加，低镁血症的发生率增高。（３）ＤＤＰ化疗后患者血清镁含量与血清尿素氮含量无相关关系。（４）低镁血症的主要临床症状为神经系统症状，其发生率占低镁血症患者的１４．０％。

erum magnesium in 79 patients of gynecologic neoplasms treated with cisplatin and their controls was measured,The results showed:(1) the average value of serum magnesium in patients following chemotherapy with cisplatin was significantly lower than in the controls;(2)the incidence of hypomag-nesemia was positively correlated with the number of the courses and the total dosages of chemothe-rapy,being 52.9%after one to three courses of treatment and 92.0% after more than six courses of treatment;(3)the incidence of hypomagnesemia was directly related with the severity of gastroin-testinal disorders;(4) serum magnesium following cisplatin chemotherapy was not correlated with serum blood urea nitrogen(BUN).Hypomagnesemia is clinically characterized by symptoms of the nervous system which are found in 14.0% of hypomagnesemic patients.