生殖道沙眼衣原体感染与输卵管性不孕关系的研究

Ralationship between Chlamydial Infection in Female Genital Tract and Tubal Infertility

应用单克隆抗体免疫荧光法，检测经腹腔镜检查的４８例不孕病人的生殖道沙眼衣原体（衣原体），其中输卵管性不孕３２例（观察组），其它原因不孕１６例（对照组）。结果：两组宫颈衣原体阳性率分别为３１．３％和１２．５％，差异无显著意义（Ｐ＞０．０５）。观察组生殖道至少有一部位的衣原体阳性率为３２．５％，明显高于对照组的１０．２％，差异有极显著意义（Ｐ＜０．０１）。观察组输卵管衣原体阳性率为６６．７％，高于组内其他部位及对照组的输卵管阳性率，差异有显著意义（Ｐ＜０．０５）。提示：输卵管为衣原体感染的高发部位。女性生殖道沙眼衣原体感染引起的输卵管炎及梗阻，是输卵管性不孕的主要原因之一。早期腹腔镜检查，是及时诊断及治疗不孕症的关键。

bjective To detect the incidence of chlamydial infection in female genital tract and it’s relation- ship with tubal infertility. Methods Fourty-eight in fertile women underwent laparoscopies were divided into study group(n=32)and control group(n=16).Samples were taken from the upper genital tract(including en- dometrium,tubal fimbriae, peritoneal fluid and pelvic adhesion)and lower genital tract(cervix).The monoclonal direct immunofluorescent method was used to assay chlamydia trachomatis the results of these two groups were compared.Resutls The positive percentage of cervical clamydial infections between the two groups were not significant lydifferent(P>0.05). But there showed a significant difference between the two groups if compared by the incidence of the whole genital tract 32.5%and 10.2%(P<0.01).The tubal positive percentage is 66.7%in the study group. Which is the highest among other locations such as cervix,en- dometrium,etc(P<0.05)。Conclusion This study indicates that fallopian tubeis a high prevalent site of chlamydial infection,and chlamydial infection in female genital tract is a principal pathogenic factor of tubal infertility, Earl ylaparoscopy for tubal infertility and chlamydia trachomatis sampling is the key methed for early diagnosis and treatment of chlamydia trachomatis.