生殖系统原发性恶性淋巴瘤15例临床分析

Primary Malignant Lymphoma of the Female Genital Tract Clinical Anal ysis of 15 Cases

回顾分析１９８０～１９９４年收治的１５例女性生殖系统原发性恶性淋巴瘤，７例发生于宫颈，２例发生于阴道，３例发生于卵巢，另外，外阴、子宫内膜和盆腔各１例。分别给予综合治疗，８例行放疗加化疗，３例行手术加放疗加化疗，３例卵巢恶性淋巴瘤行手术加化疗，１例盆腔恶性淋巴瘤行手术加放疗。结果：２例生存＞５年，３例生存＞３年，６例１年内恶化或死亡，４例治疗后不到２年，仍在随访中。提示：卵巢恶性淋巴瘤较生殖系其它部位的淋巴瘤预后差。化疗－放疗－化疗的序贯治疗适合于宫颈、阴道、外阴的淋巴瘤治疗；对于高度恶性的淋巴瘤应选择高强度的化疗，对伴有较大宫颈肿瘤的患者，应及早放疗。

Objective To review fifteen cases with primary malignant lymphoma of the female genitaI tract at Cancer Hospital,Chinese Academy of Medical Sciences from 1980～1994。Methods This is a clinical retrospiective analysis.There were 7 cases of lymphoma originating in the cervix,2 in the vagina,3 in the ovary,1 in the vulva, endometrium and pelvic cavity respectively.All of the 1 5 cases were given combination therapy. 3 ovarian lymphoma were treated by surgery and chemotherapy, 2 cervical lymphoma and 1 endometrial lymphoma by surgery, chemotherapy and radio-therapy,1 pelvic lymphoma by surgery and radiotherapy,others by radiotherapy and chemotherapy;Results Two patients are living more than 5 years,3 patients more than 3 years。 4 patients were followed up for less than 2 years and 6 patients relapsed or died。Concl usions The prognosis of ovarian lymphoma is worse than that of other genital sites。 Con-binel and sequential chemotherapy-radiotherapy-chemotherapy is the proper treatment sequence for lym-phoma of the cervix, vagina and vulva, Extensive chemotherapy may be an appropriate choice for highly malignant pathologicaI type,Radiation should be given early for large cervical lymphoma.