多囊卵巢综合征患者葡萄糖耐量试验前后血中神经肽类的变化

Responses of somatostatin,β-Endorphin and Dynorphin A to A Glucose Load in Two Groups of Women with Polycystic Ovarian Syndrome

为了研究多囊卵巢综合征（ＰＣＯＳ）的黄体生成激素（ＬＨ）及胰岛素（ＩＮＳ）升高与伸经肽的关系，我们检测了ＬＨ／卵泡刺激素（ＦＳＨ）≥３的ＰＣＯＳ患者（１型组）３０例，ＬＨ／ＦＳＨ＜３的ＰＣＯＳ患者２５例（２型组），及正常妇女１５例（对照组）葡萄糖耐量试验前后外周血中ＩＮＳ、生长抑素（ＳＳ）、β－内啡呔（β－ＥＰ）和强啡呔Ａ（ＤｙｎＡ）的变化。结果：１型组的ＬＨ与ＳＳ呈负相关性（ｒ＝－０．５１，Ｐ＜０．０５），２型组ＬＨ与β－ＥＰ也呈负相关性（ｒ＝－０．４９，Ｐ＜０．０５）；葡萄糖耐量试验后，１型组β－ＥＰ和ＤｙｎＡ较对照组升高，２型组的ＳＳ较对照组有相对不足。提示：内源性ＳＳ下降及β－ＥＰ和ＤｙｎＡ升高，可能导致ＰＣＯＳ的ＬＨ及ＩＮＳ的升高。

bjectives To investigate the relationship between elevated luteinizing hormone (LH) , hyperinsu-linemia and neuropeptides in patients with polycystic ovarian syndrome (PCOS) .Methods An oral glucose(100g) tolerance test(OGTT) was performed in 15 normally menstru-ating women (control) and 30 PCOS women with LH/follicle stimulating hormone (FSH) ratio greaterthan 3 (group1) and 25 PCOS subjects with the ratio<3 (group 2) . The responses of insulin,somato-statin (SS) , β-endorphin (β-EP) and dynorphin A(Dyn A) during OGTT were measured by RIA.Results In basal state, significant negative correlations were found between LH and SS ( r=-0.51, P< 0.05) in group 1 and between LH and β-EP (r=-0.49, P < 0.05) in group2. During OGTT, PCOS women had a greater β-EP and Dyn A responses in group 1 and an impaired SS response in group 2 as compared with the control.Conclusion These data suggested lower endogenous SS, higher β-EP and Dyn A may lead to ele-vation of LH and insulin secretions in patients with PCOS.