青少年特发性脊柱侧弯患者椎旁肌中肌梭的研究

Muscle Spindles in Adolescent Idiopathic Scoliosis

通过光镜对取自１２例ＡＩＳ患者、４例ＣＳ患者及６具青少年尸体标本椎旁肌样品中的肌梭进行观察，在ＡＩＳ及ＣＳ患者椎旁肌中发现部分肌梭结构改变且侧弯角度＞５０°者更明显，尸体标本中肌梭结构正常。ＡＩＳ患者椎旁肌中肌梭数与ＣＳ患者、尸体标本相比较少，后二者无显著性差异。统计分析表明，ＡＩＳ患者椎旁肌中肌梭数与侧弯角度、取样位置无明显相关。由此认为，ＡＩＳ患者椎旁肌中肌梭结构的改变为侧弯的继发病变，肌梭数的减少可能是侧弯发生的原因之一。

AbstractThe etiology of adolescent idiopthic scoliosis (AIS)isunknowm.The quality and quantity of the muscle spindlesin paraspinal muscle biopsy samples taken from 12 AISpatients,4 congenital scoliosis (CS)patients and 6 adoles-cent specimen had been examined by light microscope.Thepathological structure alterations of muscle spindies werefound in some AIS and CS petients。The change appearedto be worse in patients with Cobb’s angle more than 50degrees.The muscle spindles in adolescent specimen werenormal The number of muscle spindies in AIS patients issignificantly fewer than in CS patients.Statistical analysisshowed that in AIS patients,the number of muscle spindlesis not related to the sites of muscle samples and not relatedto the degree of scolitic curve .These results showed thatthe pathological structure alteations of muscle spindleswere secondary adaptations to abnomal growth of thespine. The tower number of muscle spindles may be one of the factors developing the spine deformity.Clearly ,furtherexamination is necessary.