抗生素在骨与关节中浓度分布的实验观测

The Distribution of Antibiotics within Bone and Joint Tissues:An Experimental Study

本实验用健康成年新西兰家兔３６只，经静脉推注三种不同类抗生素。不同时间取静脉血并处死动物采取肌肉、骨及关节标本。用微生物法测定血清及组织中浓度，并对预防性抗生素使用的给药时间、方法、剂量及药物选择进行探讨。实验结果表明头孢拉定较庆大霉素及环丙氟哌酸的骨与关节渗透性好，并可在骨与关节中维持较长时间的有效浓度。其结果为临床预防性抗生素使用提供了参考依据。

AbstractThirty-six New Zealand rabbits were randomly di-vided into 3 groups given 3 kinds of IV injections ofantibiotics,cephradine,geiitamycin and ciprofloxacin。Specimens of venous blood,muscles,bone and jointtissues were procured 30,60 and 120 minutes after theinjections,The concentratioris of the antibiotics inserum and tissues were determined by microbiologicalmethods,The results showed that,cephradine hadmore active penetration into bone and joint tissues andcould maintain the effective concentration for a muchlonger period than gentamycin and ciprofloxacin,Theconclusion of this study is helpful to the orthopedicsurgeons for the selection of the appropriate antibioticsfor prophylactic purpose following surgery.