呼吸衰竭心肌酶谱变化的研究

Changes and clinical significance of serum enzyme levels in patients with respiratory failure

目的测定65例六项血清心肌酶变化在呼吸衰竭中的价值。方法应用自动生化分析仪测定血清心肌酶。结果呼吸衰竭14例(21.5%)血清谷丙氨酸转移酶(ALT)值、41例(63.0%)血清天门冬谷草氨酸转移酶(AST)值、20例(30.8%血清)乳酸脱氢酶(LDH)值、38例(58.2%)血清羟丁酸脱氢酶(HBDH)值均高于正常值上限。结论血清心肌酶谱ALT、AST、CK、LDH、CK-MB、HBDH主要存在于心肌细胞中,当心肌梗死时,血清中心肌酶活力显著增高。呼吸衰竭时这六项酶指标明显升高,与对照组相比有显著差异。临床医师应引起注意。

Objective To study the value of serum enzyme in patients with respiratory failure in hospital.Methods The levels of serum enzyme in patients with respiratory failure and the controls (general pneumonia) were quantitatively detected by automatically partielc enhanced immunoturbidimetric assay.Results Serum ALT level showed an increase in 14 (21.5%) of the patients with respiratory failure, serum AST level increased in 41 (63.0%), serum LDH level increased in 20 (30.8%), serum CK level increased in 17 (26.25%), serum CK-MB level increased in 42 (64.0%) and serum HBDH level increased in 38 (58.5%).Conclusion As respiratory failure is getting worse serum levels of ALT AST Ck CK-MB LDH HBDH were seen in gradual increase and the levels in respiratory failure was significantly higher than those of the control group. It thus should be taken into consideration by clinicians.