脑梗塞患者SPECT血流灌注显像与认知电位变化研究

RESEARCH ON THE RELATIONSHIP BETWEEN SPECT AND COGNITIONAL POTENTIAL OF PATIENTS WITH CEREBRAL INFARCTION

目的：对４６例脑梗塞病人的ＳＰＥＣＴ脑血流灌注显像及神经机能联系障碍与认知电位变化之间关系进行探讨。方法：用ＳＰＥＣＴ观察脑血流灌注情况，测得局部脑血流量（ｒＣＢＦ）比值。认知电位则采用听觉ｏｄｄｂａｌｌ模式诱发Ｐ３００波。结果：可见梗塞灶区域以及远隔部位的脑血流灌注减少，其ｒＣＢＦ比值均小于０．９。认知电位检测亦显示Ｐ３００波潜伏期延长或消失，与ｒＣＢＦ减少有明显的相关性（ｒｓ＝０．８７６，Ｐ＜０．００１）。结论：脑血流灌注减少及其神经功能联系障碍导致认知功能减退，且与ｒＣＢＦ减少的部位和范围呈正相关。

PURPOSE To discuss the relationship between the regional cerebral blood flow(rCBF),the diaschisis and the change of cognitional Potential in cerebral infarction.METHODS In 46 patients the ratio of rCBF was obtained'by brain blood per fusion SPECT imaging.The cognitional Potential was produced by evoking P300 wave with auditory Oddball model.RESULTS The rCBF in infarct and its surrounding area decreased.The ratio of rCBF was less than 0.9.The detection of cognitional Potential showed that the latency of P300 was delayed or negative.There was a significant correlation between the change of rCBF and the latency of P300(rs=0.876,P<0.001).CONCLUSIN The hypoperfusion of cerebral blood now and diaschisis resulted in the cognitive impairment. There was a positive correlation between the cognitive impairment and the site and magnitude of decreased rCBF.