肠内免疫营养液在胃肠道恶性肿瘤病人围手术期的应用30例

Appilcation of Enteral Immunization Nutrient Fluids on Perioperative Patients with Malignant Gastrointestinal Tract Tumor

目的探讨围手术期给予肠内免疫营养液对胃肠道恶性肿瘤手术病人机体免疫功能及并发症的影响。方法将60例胃肠道恶性肿瘤病人随机分为IN组和SN组,分别给予肠内免疫营养制剂及普通营养制剂,观察术前5d及术后第1天、第4天和第8天细胞和体液免疫指标、肝功能、术后并发症、肛门排便/排气时间等变化。结果IN组术后第4天和第8天IgG、IgM、CD4、NK细胞水平明显高于SN组;术后第8天血清前白蛋白和白蛋水平IN组高于SN组(P<0.05),而术后并发症发生率IN组(30.0%)低于SN组(56.7%),肛门排便/排气时间两组无差异。结论术前及术后给予肠内免疫营养支持,可提高胃肠道恶性肿瘤病人术后免疫力,减少并发症,提升血清前白蛋白和白蛋白水平。

Objective To probe into the effect of enteral immune nutrition fluids on immune functions and complications of patients with malignant gastrointestinal tract tumor. Method A total of 60 patients with malignant tumor of gastrointestinal tract were selected and divided into enteral immunization nutrient group(IN) and enteral common nutrient group (SN) randomly,and were given enteral immunization nutrient fluids and enteral common nutritive fluids respectively. Then items including cellular immunity, humoral immunity, liver function,postoperative ,compilcations, defecation and anal exhaust time of all patients were monitored on five days before operation, the first, fourth and eighth days after operation. Result The IgG, IgM, CD4 and NK cells levels of patients in IN group were much higher than that in SN group on the fourth and eighth days after operation. The human serum prealbumin and albumen levels of IN group patients were much higher than that of SN group on the eighth day after operation(P<0.05). The incidence of postoperative complications of patients in IN(30.0%) were lower than that of patients in SN group(56.7%). There was no difference in terms of defecation time and anal exhaust time between the two group patients. Conclusion It showed that to perform enteral immunization nutrient supports for patients with malignant tumor of gastrointestinal tract before and after operation could enhance their postoperative immunity, reduce the complications and raise human serum prealbumin and albumen of them.