云南锡矿矿工肺癌实验病因学系列研究

Etiological studies on Yunnan tin miners’lung cancer .

为探明云南锡矿矿工肺癌高发的病因，进行了一系列实验性肺癌研究，总结如下：作为模型，甲基胆蒽，苯并芘及二乙基亚硝胺均能诱发金仓鼠肺癌。实验性肺癌病因研究中，云锡矿粉及其所含砷、铅、铁、铝、钛、锌、铬、锰、锆、镍、镉、铍、钴、银、银等１５种无机化学成分（代号ＣＭ＿１）和砷、铅、铁、铬、镍、镉、被等７种无机化学成分（代号ＣＭ＿２）均可诱发金仓鼠肺癌。ＣＭ＿１及ＣＭ＿２的Ａｍｅｓ试验、细胞转化试验均为阳性。炼厂烟尘Ａｍｅｓ试验及诱癌实验亦均为阳性，表明云锡矿粉及其部分成分的混合尘和炼厂烟尘均有致肺癌效应。因此云锡矿工肺癌病因应为多因素综合作用所致。

here is a high incidence of lung cancer amongYunnan tinminers. The results showed: as amimalmodels, methylcholanthrene, 3, 4 BaP and diethylni-trosamine could successfully induce lung cancer in ham-sters. In the etiofogical investigations of experimentallung cancer, Yunnan tin mine dust containing 15 inor-ganic chemical elements as As, Pb, Fe, AI, Ti, Zn ,Cr, Mn, Zr, Ni, Cd, V, Be, Co and Ag (CM_1) or 7inorganic chemical elements as As , Pb , Fe , Cr, Ni , Cdand Be (CM_2) could induce lung cancer in hamsters too.Ames test and cell transforiziation test of CM_1 and CM_2were positive. The mutagenicity test and cancer induc-ing experiinent of flue dust showed positive. All thesepointed out that the tin mine powder , the mixed duss ofa part of its elements (CM_1 , CM_2) and flue dust had acancer inducing effect. Therefore, the cause of Yunnantin miners' lung cancer could be the synthetic effect ofmultiple factors.