胸液中γ干扰素的测定及诱生能力的观察

Measurement of IFNY and its production capability inpleural effusion.

观察了不同病因胸液中γ干扰素（ＩＦＮγ）水平及单个核细胞诱生ＩＦＮγ的能力，结果显示结核性胸液中ＩＦＮγ水平及单个核细胞产生ＩＦＮγ的能力均较其它病因胸液明显增高，而外周血无可测ＩＦＮγ，血中单个核细胞对结核菌素纯蛋白衍生物（ＰＰＤ）刺激产生ＩＦＮγ的能力受到抑制。提示结核性胸膜炎的局部细胞免疫功能增强，ＩＦＮγ在局部抗分支杆菌感染中起一定作用。胸液中ＩＦＮγ测定在结核性胸膜炎与恶性胸液鉴别诊断中有一定参考价值。

FNy levels and IFNy production capability werestudied. The results showed that IFNY levels, IFNYproduction in the tuberculous pleurisy (n=30) were sig-nificantly higher than those in the malignant pleural ef-fusion (n= 23) and the pleural transudate. However,there was no detectable IFNy in the blood, IFNy pro-duction were lower in the blood than in the pleural effu-sion. The finding suggests that IFNy may play an im-portant role in local anti-mycobacterial infection.