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新型α-乙氧羰基-γ-芳氧甲基-γ-丁内酯的合成

Synthesis of Novel α-Ethoxycarbonyl-γ-aroxymethyl-γ-butyrolactone Derivatives
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摘要 3-芳氧基-1,2-环氧丙烷与丙二酸二乙酯在乙醇钠存在下反应,合成了6个新型α-乙氧羰基-γ-芳氧甲基-γ-丁内酯,收率47%～89%.其结构经1H NMR, IR和MS表征. A series of novel α-ethoxycarbonyl-γ-aroxymethyl-γ-butyrolactone derivatives were synthesized in 47%～89% yields by ring opening-cyclization of 2-(aroxymethyl)oxirane derivatives with diethyl malonate and the structures were confirmed by ~1H NMR, IR and MS.
作者 沙磊 赵宝祥 谭伟 焦培福 万茂生 苏磊
机构地区 山东大学化学与化工学院有机化学研究所 山东省农药研究所
出处 《合成化学》 CAS CSCD 2005年第4期344-348,共5页 Chinese Journal of Synthetic Chemistry
基金 山东省自然科学基金资助项目(Z2002D05) 教育部重点资助项目
关键词 区域选择性 环氧丙烷 丙二酸二乙酯 Γ-丁内酯 立体异构体 合成 regioselectivity epoxy diethyl malonate γ-butyrolactone stereoisomer synthesis
分类号 O621.3 [理学—有机化学]
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参考文献35

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合成化学
2005年 第4期

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