夜间哮喘患者昼夜肺功能与血清嗜酸阳离子蛋白含量改变探讨

PEF and seruln ECP changes in nocturnal asthlnatlcs.

检测夜间哮喘患者昼夜肺功能和气道反应性变化及血清嗜酸阳离子蛋白（ＥＣＰ）浓度改变，探讨嗜酸细胞与夜间哮喘的关系。结果表明，夜间哮喘患者最大呼气流量（ＰＥＦ）在４时左右降至最低；４时时乙酰甲胆碱－ＰＣ＿（２０）值明显低于１６时，血清ＥＣＰ浓度在４时升至最高。４时和１６时的ＰＥＦ下降百分比与两时间点血清ＥＣＰ浓度变化呈显著相关。提示：夜间嗜酸细胞释放ＥＣＰ增多可能是夜间哮喘患者肺功能周期性改变的重要因素之一。

e had investigated the serum ECP and peak expi-ratory flow rate in 20 patients with nocturnal asthma.Changes of PEF were measured in every 2 hours aroundthe whole day, and the blood samples were obtained at4:00 and 16:00 to measure the serum ECP level and theperipheral Eo numbers. In addition,10 asthmatics aswell as normal subjects received methacholine challengeat 4:00 and 16:00.It was found that the PEF reachedthe fowest point at 4:00 and obviously less than that at16:00(187.50±120.31 L/min vs 313.00 ± 108.14L/min,P<0.o5),that the airway reactivity at 4 : 00was significantly higher than at 16 : 00(P<0.05)andthe difference of MCH-PC_(20) between the two time pointswas 0. 34±0.31mg/ml,that the serum ECP Ievel at 4:00 was obviously higher than that at 16:00(11.14±7.40 μg/ml vs 5.49±4. 12 μg/ml,P<0. 05). Thechange rate of PEF markedly related to the change ofserum ECP between the two time points (r=0.61, P<0. 05);The findings suggested that the activation of Eoand its release of ECP might be effect of the circadian-rhythmic change of pulmonary functions in nocturnalasthma.