利尿剂和镇静剂对慢性呼吸衰竭患者带3蛋白阴离子转运功能的影响

The effect of furosemide aud valium on band 3 proteinanion transport function in chronic respiratory failure patients

为探讨药物对带３蛋白阴离子交换功能的影响及其临床意义，为临床正确治疗提供依据。对临床呼吸系疾病常用药物进行了筛选实验。结果表明，速尿、双氢克尿塞、安定可快速、可逆地抑制带３蛋白阴离子转运功能，其作用机制是通过药物与带３蛋白阴离子转运系统的两个位点相互结合完成。临床上使用利尿剂、镇静剂为肺性脑病的常见诱因，可能与这些药物抑制阴离子交换，减少ＣＯ＿２排出有关。因此肺功能不全，特别是肺心病Ⅱ型呼吸衰竭患者，应慎用此类药物。

n order to explore the effect ofdrugs on band 3protein anion transport function and its clinical signifi-cance,several common drugs such as furosemide,hy-drochlorothiazide, etc, were tested.The results demon-strated that furosemide,hydrochlorothiazide and valiumcould inhibit rapidly and reversibly the anion transportfunction of band 3 protein and led to ex-change restriction. The mechanism of action of thedrugs was thought to be an interaction between drugsand the two sites of band 3 protein anion transport sys-tem, The reason that pulmonary encephalopathy was in-duced by diuretics and sedatives may be related to the inhibitton of anion transport by the drugs and reducedCO_2 elimination,It was necessary to be careful in usingthese drugs in the patients with impaired lung function,especially the patients of cor pulmonale with type Ⅱ res-piratory failure.