遗传毒理学研究在牙科材料生物学鉴定的应用（三种细菌学短期致突变试验的组合应用）

Usage of the genotoxilogical studies in the biologicalevaluation of dental materials

应用近年新发展起来的以不同遗传毒理学终点为检测目标的三种短期致突变试验Ａｍｅｓ试验、枯草杆菌ＤＮＡ重组修复试验和ＳＯＳ显色法，将它们配套成组，对牙髓治疗常用药甲醛、戊二醛和间苯二酚进行了致突变初筛分析。证明甲醛和戊二醛为致突变物。发现间苯二酚不但本身无致突变作用，还具有桔抗某些致突变物的作用。并对上述三种短期试验的组合应用进行了介绍和评价。

AbstractThe salmonella mutagenicity test (Ames test) , theBacillus subtilis repair test and SOS chromotest are threesorts of sort-teim mutagenic test , which were developedrecently and had their individual terminal point to exam-ine genotoxins. A battery of short-term tests was madeup of these three mutagenic tests to examine the muta-genity of formaldehyde , glutaraldehydeand resorcinal.The results verified formaldehyde and glutaraldehydewere genetoxins , and discovered resorcinal not only hadno mutagenicity, but also had the antimutagenicity tosome genotoxic agents. In addition, the methods ofthree tests were described and the use of the battery wasintroduced and evaluated.