MMP-2和MMP-3在非小细胞肺癌组织中的表达及意义

Expression of MMP-2 and MMP-3 in human non-small cell lung cancer and its significance

目的探讨基质金属蛋白酶(matrixmetalloproteinases,MMPs)MMP-2和MMP-3在肺癌组织中的表达及与患者临床病理特征的关系。方法用免疫组化S-P染色技术对45例非小细胞肺癌标本及20例癌旁正常肺组织标本中MMP-2和MMP-3的表达水平进行检测,并结合患者的临床病理资料对其结果进行对比分析。结果MMP-2和MMP-3在肺癌组织中的阳性表达率明显高于癌旁正常肺组织(P<0.05),MMP-2的表达与肺癌临床分期、组织分化程度、淋巴结转移有密切关系(P<0.05〉,而MMP-3的表达与上述临床病理特征无明显关系(P>0.05)。结论MMP-2、MMP-3均是良好的肺瘤标记物,MMP-2与肺癌侵袭转移关系密切,MMP-3可能在肺癌侵袭转移中作用不显著。

Objective To investigate the expression of MMP-2 and MMP-3 in human non-small cell lung cancer and to evaluate the relationship between their expression and their clinicopathological features. Methods The expression of MMP-2 and MMP-3 was detected in 45 patients with NSCLC and 20 para-cancerous normal lung tissues by immunohistochemical method, and the results were compared. Results The expression of MMP-2 and MMP-3 in NSCLC tissues was significantly higher than that in para-cancerous nomal lung tissues (P<0.05); The positive expression of MMP-2 was associated with TNM stage ,pathological differentiation and lymph node metastasis(P<0.05). The expression of MMP-3 in NSCLC tissues was not associated with that of their clinicopathological features (P>0.05). Conclusion MMP-2 and MMP-3 ave good tumor markers. The expression of MMP-2 is closely correlated with the invasion and metastasis of lung carcinoma. The expression of MMP-3 may be not a critical factor which affects the invasion and metastasis of lung carcinoma.