PF方案联合放射治疗晚期食管癌的疗效观察

Therapeutic results of PF regimen chemotherapy combined with radiation therapy in the treatment of advanced esophageal carcinonma

目的探讨PF方案联合放射治疗晚期食管癌的疗效及毒副反应。方法回顾分析68例食管癌的随访资料,根据治疗方法不同分为PF方案联合放射治疗组和单纯放疗组,应用χ2检验分析肿瘤的缓解率、患者的生存率及毒副反应。结果PF方案联合放疗组在肿瘤的消失、缩小方面优于单纯放疗组,两者差异有显著意义(P<0.05)。化疗联合放疗组1、2、3、5年的生存率明显高于单纯放疗组,两者有显著性差异(P<0.05);但化疗联合放疗组较单纯放疗组消化道I-II度毒副反应发生率明显增加,差异有显著性意义(P<0.05)。结论PF方案联合放射治疗晚期食管癌是目前较为理想的治疗方案。

Objective To explore the curative effect and side-effects of PF regimen combined with radiation therapy in the treatment of advanced esophageal cancer.Methods Data of sixty eight esophageal cancer patients were analyzed retrospectively. The patients were divided into two groups based on different treatment methods. Group A received PF regimen chemotherapy combined with radiation therapy, while group B received radiation therapy only. χ~2 test was used to analyze the tumor remission rate, survival rate and side-effects.Results PF regimen chemotherapy combined with radiation therapy was more effective than radiation therapy. One, two, three and five-year survival rates of group A were significant higher than those of group B respectively. However,ⅠtoⅡgrade gastrointestinal tract toxicity of group A was more than group B.Conclusion PF regimen chemotherapy combined with radiation therapy is currently an effective method in the treatment of advanced esophageal cancer.