奥沙利铂和5-氟尿嘧啶/醛氢叶酸双周疗法治疗晚期胃癌

Semimonthly 5-fluorouracil/leucovorin combined with oxaliplatin in treatment of advanced gastric cancer

目的评价奥沙利铂和5-氟尿嘧啶/醛氢叶酸双周疗法治疗晚期胃癌的疗效及安全性。方法26例晚期胃癌患者均有可评价的病灶,25例完成下例方案:奥沙利铂85mg/m2及醛氢叶酸(LV)200mg/m2(2小时静脉滴注),随后5-氟尿嘧啶(5-Fu)400mg/m2(10分钟静注),5-Fu600mg/m2持续静脉输注22h,醛氢叶酸及5-Fu连用两天,每2周重复1次,每2次为1个疗程,所有患者至少接受2个疗程的治疗。结果完全缓解2例,部分缓解12例,总有效率56%(14/25),中位缓解期3个月。无治疗相关死亡,主要不良反应为轻度的外周神经系统感觉障碍,恶心呕吐,白细胞及血红蛋白降低。结论奥沙利铂和5-氟尿嘧啶/醛氢叶酸双周疗法对晚期胃癌疗效确切,毒副反应轻,拓展了晚期胃癌患者化疗方案的选择。

Objective To evaluate the efficacy and the safety of oxaliplatin combined with semimonthly 5-fluorouracil (5-FU)/leucovorin(LV) for patients with advanced gastric cancer(AGC). Methods Of the 26 eligible patients with assessable or measurable AGC, 25 received oxaliplatin 85mg/m^2 on day1 and LV 200 mg/m^2 on day1,2(2-hour intravenous infusion) followed by 5-FU bolus 400mg/m^2 on day1,2 (10 minute infusion) and then 5-FU 600mg/m^2 on day1,2 (22 hour continuous infusion). Cycles were repeated at 2-week intervals. One cycle consisted of twice chemotherapy regimens. Treatment was continued for at least two cycles in all enrolled cases. Results Of the 25 evaluable patients, there were two complete responses and twelve partial responses (responses rate 56%, 14/25). The median duration of response was three months. No treatment-related death occurred, The major adverse effects were mild peripheral neuropathy、nausea/vomiting and myelosuppression. Conclusion Semimonthly 5-FU/LV combined with oxaliplatin shows good efficacy and acceptable safety in AGC patients, this regimen may be introduced into AGC patients, which let us have more choice for these patients in treatment.