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肥大细胞对肺成纤维细胞生长的影响 被引量:4

THE EFFECT OF MAST CELLS ON THE GROWTH CULTURED LULNG FIBROBLASTS
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摘要 应用光镜、电镜、细胞生长曲线和同位素技术等方法,研究了大鼠腹腔肥大细胞(PMC)及PMC上清(含PMC释放的介质)对培养的同源肺成纤维细胞(LFb)生长的影响。结果表明,实验组LFb呈复层生长,H-TdR掺入量和细胞密度均明显大于对照组(P<0.001)。提示PMC释放的活性介质可能含有促进LFb增生的因子。 41ee Mast cells isolated from peritoneal cavity(PMC)of rats and PMC supernatant were co-cultured with rat lung fibroblasts (LFb) separately,The effect of PMC and its supernatant on the growth of LFb was studied with light microscopy, electron mi-croscopy,growth curve and3H-thymidine labelling technique. The results showed that there were stratification increase in3H-TdR incorporation and cellular density in LFb of experimental groups , significantly different from the control(P<0.001).It is suggested that the medium released from PMC may contain some factors which promote LFb proliferation.
出处 《中华劳动卫生职业病杂志》 CAS CSCD 1995年第3期149-150,共2页 Chinese Journal of Industrial Hygiene and Occupational Diseases
基金 国家自然科学基金和CMD资助
关键词 矽肺 肥大细胞 成纤维细胞 肺纤维化 组胺 Mast cells Pneumoconiosis Fibroblast Pulmonary fibrosis Histamine
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同被引文献24

  • 1赵厚德,郝智慧,郑海发,孙辉.对环磷酰胺引起低白细胞大鼠的白细胞分类变化研究[J].中国实验动物学杂志,2002,12(5):285-287. 被引量:3
  • 2郑晖,钱仲棐.肥大细胞与肺成纤维细胞共育方法[J].细胞生物学杂志,1993,15(4):186-187. 被引量:4
  • 3范开.细菌脂多糖对小鼠巨噬细胞生长的调节作用[J].中华肝脏病杂志,1996,4(2):94-96. 被引量:3
  • 4陈广文,临床与实验病理学杂志,1998年,14卷,2期,114页
  • 5钱仲裴,中华劳动卫生职业病杂志,1995年,13卷,2期,149页
  • 6钱仲裴,中华病理学杂志,1992年,12卷,6期,346页
  • 7Metcalf DD,Lewis RA,Silbert JE,et al.Isolation and characterization of heparin from human lung J Clin Invest,1979:64(10):1537-1547.
  • 8Yuko Yamashita, Kazuya Nakogomi, Taich/Takeda, et al Efect of heparin on pulmonary fibroblasts and vascular cells. Thorax, 1992,47(8):634-639.
  • 9Piguet PF. Expression and localition of tumor necrosis faetoralpha and its mRNA in idiopathic pulmonary fibrosis. Am J Pathol, 1993:143(3):1651-655.
  • 10屈锋 任满意 郑金瑜.大鼠呼吸道给药方法的建立与改进.临床与实验病理学杂志,2000,:234-234.

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