摘要
利用三硝基甲苯血红蛋白加合物（ＴＮＴ－Ｈｂ）这一生物标志物对三硝基甲苯（ＴＮＴ）的生产现场进行了分子流行病学调查，目的在于观察加合物水平与白内障发生率之间的关系。现场调查结果证实ＴＮＴ－Ｈｂ的水平与ＴＮＴ所致眼白内障的发病率和晶体损害程度都密切相关，不但为ＴＮＴ所致白内障的机理探讨提供了依据，也提出ＴＮＴ－Ｈｂ这一生物标志物可作为危险性评价的参考指标。
A molecular epidemiologic study was conducted in a plant,in which TNT hemoglobin adduct was
used as a biomarker to studyadduct-response relationship.TVT cataract was used as an indicator
of health effect.The results of this study showed that there isa good correlation between the level
of TNT-Hb adduct and the prevalence of cataract caused by TNT.Therefore,it could be usedfor its
risk assessment.
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
1995年第5期260-261,共2页
Chinese Journal of Industrial Hygiene and Occupational Diseases
基金
国家七五重点攻关课题
国家自然科学基金
