Acivicin对大鼠尿汞排泄影响的实验研究

EFFECT OF ACIVICIN ON URINE MERCURY EXCRETION IN RAT

通过给大鼠腹腔注射ＨｇＣｌ２和Ａｃｉｖｉｃｉｎ，观察了Ａｃｉｖｉｃｉｎ对γ－ＧＴＰ活力及ＨｇＣｌ２，代谢的影响。结果表明，按２５ｍｍｏｌ／ｋｇ注射Ａｃｉｖｉｃｉｎ后１ｈ，肾γ－ＧＴＰ活力下降至正常的３６％左右，５０μｍｏｌ／ｋｇ组下降更加显著，８ｈ后恢复正常。给Ａｃｉｖｉｃｉｎ组肝汞、肾汞含量均显著下降，尿汞含量显著增加。提示Ａｃｉｖｉｃｉｎ通过有效地抑制肾γ－ＧＴＰ活力，影响ＨｇＣｌ２在体内的代谢，加速尿汞排出速度，降低肝汞、肾汞蓄积量。

In order to study the influence of acivicin on the activity of γ-GTP and metablism of HgCl2,female rats were administered with HgCl2 alone and coadministered with acivicin intraperitoneally.At 1 h after administration,the activity of γ-GTP in 25 μmol/kg acivicin group decreased to 36%,and in 50 μmol /kg decreased more significantly.8 h later recovered to normal.The mercury con-tents of liver and kidney dropped significantly in acivicin groups,whereas urine mercury content increased markedly.These results suggested that acivicin may influenc the metablism of inorganic mercury through inhibiting γ-GTP and promoting urine mercury ex-