摘要
通过给大鼠腹腔注射HgCl2和Acivicin,观察了Acivicin对γ-GTP活力及HgCl2,代谢的影响。结果表明,按25mmol/kg注射Acivicin后1h,肾γ-GTP活力下降至正常的36%左右,50μmol/kg组下降更加显著,8h后恢复正常。给Acivicin组肝汞、肾汞含量均显著下降,尿汞含量显著增加。提示Acivicin通过有效地抑制肾γ-GTP活力,影响HgCl2在体内的代谢,加速尿汞排出速度,降低肝汞、肾汞蓄积量。
In order to study the influence of acivicin on the activity of γ-GTP and metablism of
HgCl2,female rats were administered with HgCl2 alone and coadministered with acivicin
intraperitoneally.At 1 h after administration,the activity of γ-GTP in 25 μmol/kg acivicin group
decreased to 36%,and in 50 μmol /kg decreased more significantly.8 h later recovered to
normal.The mercury con-tents of liver and kidney dropped significantly in acivicin
groups,whereas urine mercury content increased markedly.These results suggested that
acivicin may influenc the metablism of inorganic mercury through inhibiting γ-GTP and
promoting urine mercury ex-
出处
《中华劳动卫生职业病杂志》
CAS
CSCD
1995年第5期269-270,共2页
Chinese Journal of Industrial Hygiene and Occupational Diseases