高血压患者红细胞变形能力与红细胞内钙浓度的关系

The relationship between red cell deformability and intracellular calcium in patients with essential hypertension

应用ＤＸＣ－３００Ａ核孔膜红细胞变形能力测定仪，对老年前期、老年期健康人和高血压患者红细胞变形能力进行了测定，并对可导致红细胞变形能力异常的因素──红细胞内Ｃａ￣（２＋）、Ｍｇ￣（２＋）浓度进行了测定。结果显示，健康老年人红细胞滤过指数（ＦＩ）、红细胞内Ｃａ￣（２＋）较健康老年前期者明显增高（Ｐ＜０．００１及＜０．０１），ＦＩ与红细胞内Ｃａ￣（２＋）及年龄、ＦＩ与红细胞内Ｃａ￣（２＋）之间均呈正相关。类似结果亦见于高血压病患者与健康对照组之间。结果提示，红细胞内Ｃａ￣（２＋）增高是导致红细胞变形能力降低的重要因素之一。

Abstract Red cell deformability(RCD) and intracellular calcium and magnesium (RBC-Ca2+, Mg2+1 were studied in pre-aged and aged patients with essential hypertension and healthy subjects. The results showed that red cell filtration index (FI) and RBC-Ca2+ in healthy aged were significantly higher than those in healthy pre aged (P<0.001, 0.01), there were positive correlations between FI, RBC-Ca2+ and age and between FI and RBC-Ca2+. FI in patients was higher than that in healthy control group(P<0.001) , and there were also positive correlations between FI, RBC-Ca2+ and age, and FI and RBC-Ca2+. These results suggest that the increasing of RBC-Ca2+ is an important factor leading to decreasing of RCD.